Multi-Omics for Mothers and Infants (MOMI) Consortium

A woman carries bowls on her head while holding a child, walking down a dusty path.

The MOMI Consortium is a global research initiative focused on understanding the biological mechanisms underlying adverse pregnancy outcomes (APOs), including preterm birth, pre-eclampsia, and stillbirth. These conditions disproportionately affect low- and middle-income countries (LMICs) and arise from complex, multifactorial biological processes. MOMI integrates multi-omics data from over 24,000 pregnant women enrolled in cohorts across South Asia and sub-Saharan Africa. Longitudinal maternal, fetal, and placental biospecimens were analyzed using genomics, metabolomics, proteomics, and nutrient profiling platforms, with coordinated bioinformatics support. By combining data across diverse populations and analytical approaches, the consortium aims to identify shared and site-specific biological signatures associated with APOs, supporting the development of improved diagnostics and prevention strategies to enhance maternal and infant health globally.